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Compound Detail

CHEMBL278906

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Nc1nc2nn(Cc3ccc(F)cc3)cc2c2nc(-c3ccco3)nn12

Basic Information

ChEMBL ID CHEMBL278906
Phase Preclinical
Structure Type MOL
InChI Key BJALMNZBJQDVQK-UHFFFAOYSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

349.3
MW (Da)
2.50
ALogP
8
HBA
1
HBD
100.1
PSA (Ų)
0.54
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H12FN7O
MW 349.33
Aromatic Rings 5
Heavy Atoms 26
NP-Likeness -1.93

Activity Summary

Ki 5 meas. best 8.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 8.92 8.92 1.2 3
Adenosine receptor A1
CHEMBL318
Ki 8.48 8.48 3.3 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8676354 10.1021/jm950746l Adenosine receptor A2a 2
8676354 10.1021/jm950746l Adenosine receptor A1 1
8676354 10.1021/jm950746l Adenosine receptors; A1 & A2a 1
- 10.1016/S0960-894X(01)80279-1 Adenosine receptor A1 1
- 10.1016/S0960-894X(01)80279-1 Adenosine receptor A2a 1
- 10.1016/S0960-894X(01)80279-1 Adenosine receptors; A1 & A2a 1
28626529 10.1021/acsmedchemlett.7b00138 Adenosine receptor A2a 1

Data from ChEMBL 36 via Core Engine