Compound Detail
CHEMBL280083
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Basic Information
| ChEMBL ID | CHEMBL280083 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CUYIBIIXRWZLMQ-MJGOQNOKSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
341.4
MW (Da)
2.17
ALogP
5
HBA
3
HBD
73.2
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 8.05 | 7.47 | 9.0 | 2 |
| Unchecked CHEMBL612545 | IC50 | 7.51 | 7.39 | 31.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 9.0 | nM | 8.05 | Compound was tested for neuroprotection against NMDA-Induced toxicity in culture... | 9544217 |
| Unchecked | IC50 | = | 31.0 | nM | 7.51 | Displacement of racemic [3H]CP-101606 from rat forebrain membrane N-methyl-D-asp... | 9544217 |
| Unchecked | IC50 | = | 54.0 | nM | 7.27 | Displacement of racemic [3H]CP-101606 from rat forebrain membrane N-methyl-D-asp... | 9544217 |
| Rattus norvegicus | IC50 | = | 129.0 | nM | 6.89 | Compound was tested for neuroprotection against NMDA-Induced toxicity in culture... | 9544217 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9544217 | 10.1021/jm9707986 | Unchecked | 2 |
| 9544217 | 10.1021/jm9707986 | Rattus norvegicus | 2 |
| 20692832 | 10.1016/j.bmcl.2010.07.043 | Glutamate NMDA receptor; GRIN1/GRIN2B | 2 |
Data from ChEMBL 36 via Core Engine