Assay Detail
Functional
CHEMBL780342
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Compound was tested for neuroprotection against NMDA-Induced toxicity in cultured rat hippocampal neurons.
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(3R,4S)-3-[4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl]chroman-4,7-diol: a conformationally restricted analogue of the NR2B subtype-selective NMDA antagonist (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)- 1-propanol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17703 | — | — | 2 | 8.40 |
| CHEMBL280083 | — | — | 2 | 8.05 |
| CHEMBL17833 | — | — | 1 | 7.96 |
| CHEMBL17885 | — | — | 1 | 7.70 |
| CHEMBL277787 | — | — | 1 | 7.64 |
| CHEMBL17595 | — | — | 1 | 7.60 |
| CHEMBL417630 | — | — | 1 | 6.97 |
| CHEMBL17909 | — | — | 1 | 6.80 |
| CHEMBL17812 | — | — | 1 | 6.42 |
| CHEMBL273354 | — | — | 1 | 6.27 |
| CHEMBL17798 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17703 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL17703 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL280083 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL17833 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL17885 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL277787 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL17595 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL417630 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL280083 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL17909 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL17812 | — | IC50 | = | 383.0 | nM | 6.42 |
| CHEMBL273354 | — | IC50 | = | 533.0 | nM | 6.27 |
| CHEMBL17798 | — | IC50 | = | 1000.0 | nM | 6.00 |