Compound Detail
CHEMBL280181
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Basic Information
| ChEMBL ID | CHEMBL280181 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BJSYVDIHBYVMSH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
424.5
MW (Da)
4.08
ALogP
5
HBA
0
HBD
50.6
PSA (Ų)
0.43
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095178 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 6.29 | 6.29 | 509.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 8.0 | nM | 8.1 | Inhibition of Farnesyltransferase catalyzed incorporation of [3H]-FPP into recom... | 11965368 |
| Geranylgeranyl transferase type I | IC50 | = | 509.0 | nM | 6.29 | Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporatio... | 11965368 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11965368 | 10.1016/s0960-894x(02)00154-3 | Protein farnesyltransferase | 2 |
| 11965368 | 10.1016/s0960-894x(02)00154-3 | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine