Compound Detail
CHEMBL280833
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Basic Information
| ChEMBL ID | CHEMBL280833 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZBKWJCLXDQUBBM-QUCCMNQESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
3.52
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.85
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 CHEMBL2093864 | Kd | 6.62 | 6.62 | 239.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | Kd | = | 239.88 | nM | 6.62 | Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens | 2838634 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2838634 | 10.1021/jm00402a029 | Adrenergic receptor alpha-2 | 1 |
| 2838634 | 10.1021/jm00402a029 | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine