Assay Detail
Functional
CHEMBL641537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against alpha-2 adrenergic receptor in rat vas deferens
51
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of 2-sulfonamido-1,3,4,6,7,11b alpha-hexahydro-2H-benzo[a]quinolizines as alpha 2-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 51 | 7.50 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30419 | — | — | 2 | 8.50 |
| CHEMBL30979 | — | — | 1 | 8.46 |
| CHEMBL277737 | — | — | 1 | 8.44 |
| CHEMBL280750 | — | — | 1 | 8.26 |
| CHEMBL33498 | — | — | 1 | 8.22 |
| CHEMBL30477 | — | — | 2 | 8.16 |
| CHEMBL33443 | — | — | 1 | 8.11 |
| CHEMBL283498 | — | — | 1 | 8.10 |
| CHEMBL30829 | — | — | 1 | 8.10 |
| CHEMBL285807 | — | — | 1 | 8.10 |
| CHEMBL30651 | — | — | 1 | 8.06 |
| CHEMBL442104 | — | — | 2 | 8.05 |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | 8.04 |
| CHEMBL285992 | — | — | 1 | 7.94 |
| CHEMBL33231 | — | — | 1 | 7.93 |
| CHEMBL34330 | — | — | 1 | 7.90 |
| CHEMBL287245 | — | — | 1 | 7.87 |
| CHEMBL281107 | — | — | 1 | 7.87 |
| CHEMBL34570 | — | — | 1 | 7.77 |
| CHEMBL30338 | — | — | 1 | 7.74 |
| CHEMBL282848 | — | — | 1 | 7.70 |
| CHEMBL30462 | — | — | 1 | 7.70 |
| CHEMBL30956 | — | — | 1 | 7.61 |
| CHEMBL282182 | — | — | 1 | 7.60 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.58 |
| CHEMBL30504 | — | — | 1 | 7.56 |
| CHEMBL417484 | — | — | 1 | 7.50 |
| CHEMBL286650 | — | — | 1 | 7.44 |
| CHEMBL282098 | — | — | 1 | 7.40 |
| CHEMBL30590 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30419 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL30979 | — | Kd | = | 3.467 | nM | 8.46 |
| CHEMBL277737 | — | Kd | = | 3.631 | nM | 8.44 |
| CHEMBL280750 | — | Kd | = | 5.495 | nM | 8.26 |
| CHEMBL33498 | — | Kd | = | 6.026 | nM | 8.22 |
| CHEMBL30477 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL33443 | — | Kd | = | 7.762 | nM | 8.11 |
| CHEMBL283498 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL285807 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL30829 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL30419 | — | Kd | = | 8.318 | nM | 8.08 |
| CHEMBL30651 | — | Kd | = | 8.71 | nM | 8.06 |
| CHEMBL30477 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL442104 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL10316 | IDAZOXAN | Kd | = | 9.12 | nM | 8.04 |
| CHEMBL285992 | — | Kd | = | 11.48 | nM | 7.94 |
| CHEMBL33231 | — | Kd | = | 11.75 | nM | 7.93 |
| CHEMBL34330 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL287245 | — | Kd | = | 13.49 | nM | 7.87 |
| CHEMBL281107 | — | Kd | = | 13.49 | nM | 7.87 |
| CHEMBL442104 | — | Kd | = | 15.49 | nM | 7.81 |
| CHEMBL34570 | — | Kd | = | 16.98 | nM | 7.77 |
| CHEMBL30338 | — | Kd | = | 18.2 | nM | 7.74 |
| CHEMBL282848 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL30462 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL30956 | — | Kd | = | 24.55 | nM | 7.61 |
| CHEMBL282182 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 26.3 | nM | 7.58 |
| CHEMBL30504 | — | Kd | = | 27.54 | nM | 7.56 |
| CHEMBL417484 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL286650 | — | Kd | = | 36.31 | nM | 7.44 |
| CHEMBL282098 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL30590 | — | Kd | = | 40.74 | nM | 7.39 |
| CHEMBL416403 | — | Kd | = | 54.95 | nM | 7.26 |
| CHEMBL31045 | — | Kd | = | 70.79 | nM | 7.15 |
| CHEMBL30704 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL287294 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL29950 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL440100 | — | Kd | = | 169.82 | nM | 6.77 |
| CHEMBL440101 | — | Kd | = | 234.42 | nM | 6.63 |
| CHEMBL280833 | — | Kd | = | 239.88 | nM | 6.62 |
| CHEMBL281488 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL31096 | — | Kd | = | 354.81 | nM | 6.45 |
| CHEMBL287409 | — | Kd | = | 457.09 | nM | 6.34 |
| CHEMBL284797 | — | Kd | = | 537.03 | nM | 6.27 |
| CHEMBL30905 | — | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL435357 | — | Kd | = | 1659.59 | nM | 5.78 |
| CHEMBL34577 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL283236 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL30874 | — | Kd | > | 10000.0 | nM | - |