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Compound Detail

CHEMBL30704

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CC(C)COC(=O)N(C)[C@@H]1CCN2CCc3ccccc3[C@@H]2C1

Basic Information

ChEMBL ID CHEMBL30704
Phase Preclinical
Structure Type MOL
InChI Key RAZUEGXAXYXYBC-AEFFLSMTSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

316.4
MW (Da)
3.47
ALogP
3
HBA
0
HBD
32.8
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H28N2O2
MW 316.44
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -0.22

Activity Summary

Kd 2 meas. best 7.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
Kd 7.1 7.1 79.4 1
Adrenergic receptor alpha-1
CHEMBL1907610
Kd 7.0 7.0 100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2838634 10.1021/jm00402a029 Adrenergic receptor alpha-2 1
2838634 10.1021/jm00402a029 Adrenergic receptor alpha-1 1
2838634 10.1021/jm00402a029 Adrenergic receptor alpha 1

Data from ChEMBL 36 via Core Engine