Compound Detail
CHEMBL286334
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Basic Information
| ChEMBL ID | CHEMBL286334 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UTUUPXBCDMQYRR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
373.5
MW (Da)
5.79
ALogP
3
HBA
0
HBD
31.4
PSA (Ų)
0.53
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.76
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A CHEMBL254 | IC50 | 7.76 | 7.76 | 17.5 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-AMP phosphodiesterase 4A | IC50 | = | 17.5 | nM | 7.76 | Inhibition of human recombinant phosphodiesterase 4A | 12031318 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12031318 | 10.1016/s0960-894x(02)00202-0 | 3',5'-cyclic-AMP phosphodiesterase 4A | 1 |
Data from ChEMBL 36 via Core Engine