Assay Detail
Binding
CHEMBL765482
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Inhibition of human recombinant phosphodiesterase 4A
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 7.77 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418416 | — | — | 1 | 9.52 |
| CHEMBL35562 | — | — | 1 | 9.10 |
| CHEMBL285766 | — | — | 1 | 8.60 |
| CHEMBL286998 | — | — | 1 | 8.52 |
| CHEMBL32442 | CDP840 | — | 1 | 8.40 |
| CHEMBL286119 | — | — | 1 | 8.40 |
| CHEMBL286921 | — | — | 1 | 8.32 |
| CHEMBL33419 | — | — | 1 | 8.30 |
| CHEMBL35391 | — | — | 1 | 8.30 |
| CHEMBL286118 | — | — | 1 | 8.30 |
| CHEMBL35011 | — | — | 1 | 8.15 |
| CHEMBL36559 | — | — | 1 | 8.15 |
| CHEMBL286603 | — | — | 1 | 8.15 |
| CHEMBL286421 | — | — | 1 | 8.12 |
| CHEMBL36007 | — | — | 1 | 8.10 |
| CHEMBL284386 | — | — | 1 | 8.10 |
| CHEMBL287359 | — | — | 1 | 8.10 |
| CHEMBL416399 | — | — | 1 | 8.05 |
| CHEMBL289012 | — | — | 1 | 8.00 |
| CHEMBL285488 | — | — | 1 | 7.96 |
| CHEMBL287167 | — | — | 1 | 7.92 |
| CHEMBL287026 | — | — | 1 | 7.80 |
| CHEMBL287307 | — | — | 1 | 7.77 |
| CHEMBL286334 | — | — | 1 | 7.76 |
| CHEMBL287377 | — | — | 1 | 7.72 |
| CHEMBL33021 | — | — | 1 | 7.66 |
| CHEMBL416045 | — | — | 1 | 7.57 |
| CHEMBL289453 | — | — | 1 | 7.51 |
| CHEMBL35218 | — | — | 1 | 7.40 |
| CHEMBL284506 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418416 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL35562 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL285766 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL286998 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL32442 | CDP840 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL286119 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL286921 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL33419 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL35391 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL286118 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL286603 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL36559 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL35011 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL286421 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL287359 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL36007 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL284386 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL416399 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL289012 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL285488 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL287167 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL287026 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL287307 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL286334 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL287377 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL33021 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL416045 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL289453 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL35218 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL284506 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL36077 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL32427 | — | IC50 | = | 54.6 | nM | 7.26 |
| CHEMBL445833 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL286294 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL35703 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL35346 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL433828 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL36471 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL35607 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL284973 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL35390 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL416041 | — | IC50 | = | 389.0 | nM | 6.41 |