Compound Detail
CHEMBL286752
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Basic Information
| ChEMBL ID | CHEMBL286752 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FZAAGBYLDXVMRM-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
208.1
MW (Da)
0.34
ALogP
7
HBA
2
HBD
122.3
PSA (Ų)
0.51
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.96
Ki 1 meas. best 5.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 5.96 | 5.96 | 1100.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 5.96 | 5.96 | 1100.0 | 1 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.48 | 5.48 | 3300.0 | 1 |
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | IC50 | 5.36 | 5.36 | 4400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 1100.0 | nM | 5.96 | Displacement of [3H]DCKA at N-methyl-D-aspartate glutamate receptor 1 | 9357535 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 1100.0 | nM | 5.96 | In vitro inhibition of the specific binding of [3H]AMPA to Ionotropic glutamate ... | 8632440 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 3300.0 | nM | 5.48 | Binding affinity in rat brain cortical membranes by the displacement of [3H]AMPA... | 9357535 |
| Glutamate receptor ionotropic, kainate | IC50 | = | 4400.0 | nM | 5.36 | Displacement of [3H]kainate from rat brain cortical membrane Ionotropic glutamat... | 9357535 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9357535 | 10.1021/jm970396y | Glutamate receptor ionotropic, AMPA | 2 |
| 9357535 | 10.1021/jm970396y | Glutamate NMDA receptor | 1 |
| 9357535 | 10.1021/jm970396y | Glutamate receptor ionotropic, kainate | 1 |
| 9357535 | 10.1021/jm970396y | Mus musculus | 1 |
| 9357535 | 10.1021/jm970396y | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 9357535 | 10.1021/jm970396y | No relevant target | 1 |
| 8632440 | 10.1021/jm950304+ | Glutamate receptor ionotropic, AMPA | 1 |
Data from ChEMBL 36 via Core Engine