Compound Detail
CHEMBL287671
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Basic Information
| ChEMBL ID | CHEMBL287671 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KGZWRXWYLPRJCF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
368.5
MW (Da)
4.55
ALogP
3
HBA
1
HBD
35.2
PSA (Ų)
0.57
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.83
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(4) dopamine receptor CHEMBL3361 | Ki | 6.83 | 6.83 | 148.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 5.71 | 5.71 | 1932.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(4) dopamine receptor | Ki | = | 148.0 | nM | 6.83 | In vitro binding affinity to rat Dopamine receptor D4 measured by displacement o... | 11378358 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 1932.0 | nM | 5.71 | Binding affinity to cloned human 5-hydroxytryptamine 2A receptor | 11378358 |
Literature References
Data from ChEMBL 36 via Core Engine