Assay Detail
Binding
CHEMBL671600
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In vitro binding affinity to rat Dopamine receptor D4 measured by displacement of the radioligand [3H]spiperone
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of potent and selective dopamine D(4) antagonists as candidate radioligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.23 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL435949 | — | — | 1 | 8.85 |
| CHEMBL28997 | — | — | 1 | 8.64 |
| CHEMBL29808 | — | — | 1 | 8.55 |
| CHEMBL282424 | — | — | 1 | 8.48 |
| CHEMBL28607 | — | — | 1 | 8.44 |
| CHEMBL267014 | L-745870 | — | 1 | 8.43 |
| CHEMBL28651 | — | — | 1 | 8.33 |
| CHEMBL282829 | — | — | 1 | 8.30 |
| CHEMBL28833 | — | — | 1 | 8.17 |
| CHEMBL283036 | — | — | 1 | 7.47 |
| CHEMBL287671 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL435949 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL28997 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL29808 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL282424 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL28607 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL267014 | L-745870 | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL28651 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL282829 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL28833 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL283036 | — | Ki | = | 34.1 | nM | 7.47 |
| CHEMBL287671 | — | Ki | = | 148.0 | nM | 6.83 |