Compound Detail
CHEMBL288704
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Basic Information
| ChEMBL ID | CHEMBL288704 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ARAWZUUSXRTRLM-AWEZNQCLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
338.4
MW (Da)
2.43
ALogP
4
HBA
1
HBD
50.8
PSA (Ų)
0.79
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 8.85 | 8.565 | 1.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 1.41 | nM | 8.85 | Compound was evaluated for binding affinity towards dopamine receptor D2 in stri... | 1827843 |
| D(2) dopamine receptor | Ki | = | 5.27 | nM | 8.28 | Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes ... | 1827843 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1827843 | 10.1021/jm00109a013 | D(2) dopamine receptor | 2 |
Data from ChEMBL 36 via Core Engine