Assay Detail
Binding
CHEMBL675740
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Displacement of [3H]- spiperone from dopamine receptor D2 of striatal membranes without sodium chloride
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 8.53 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44237 | EPIDEPRIDE | — | 1 | 9.18 |
| CHEMBL289330 | — | — | 1 | 9.12 |
| CHEMBL43506 | — | — | 1 | 9.11 |
| CHEMBL42448 | — | — | 1 | 9.10 |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.00 |
| CHEMBL42260 | — | — | 1 | 8.89 |
| CHEMBL42953 | — | — | 1 | 8.36 |
| CHEMBL288704 | — | — | 1 | 8.28 |
| CHEMBL43552 | — | — | 1 | 8.16 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.48 |
| CHEMBL295621 | — | — | 1 | 7.18 |
| CHEMBL2114460 | — | — | 1 | - |
| CHEMBL2114461 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44237 | EPIDEPRIDE | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL289330 | — | Ki | = | 0.76 | nM | 9.12 |
| CHEMBL43506 | — | Ki | = | 0.77 | nM | 9.11 |
| CHEMBL42448 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL8946 | ETICLOPRIDE | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL42260 | — | Ki | = | 1.28 | nM | 8.89 |
| CHEMBL42953 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL288704 | — | Ki | = | 5.27 | nM | 8.28 |
| CHEMBL43552 | — | Ki | = | 6.98 | nM | 8.16 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 32.8 | nM | 7.48 |
| CHEMBL295621 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL2114460 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL2114461 | — | Ki | > | 10000.0 | nM | - |