Compound Detail
CHEMBL29213
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Basic Information
| ChEMBL ID | CHEMBL29213 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CVZIRDLTVVTXNF-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
304.4
MW (Da)
2.94
ALogP
2
HBA
1
HBD
53.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; alpha-1/beta-2/gamma-2 CHEMBL2095172 | Ki | 6.42 | 6.42 | 380.0 | 1 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 CHEMBL2094130 | Ki | 6.17 | 6.17 | 680.0 | 1 |
| GABA-A receptor; alpha-3/beta-3/gamma-2 CHEMBL2094120 | Ki | 6.14 | 6.14 | 720.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; alpha-1/beta-2/gamma-2 | Ki | = | 380.0 | nM | 6.42 | Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant... | 10890169 |
| GABA-A receptor; alpha-2/beta-3/gamma-2 | Ki | = | 680.0 | nM | 6.17 | Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombina... | 10890169 |
| GABA-A receptor; alpha-3/beta-3/gamma-2 | Ki | = | 720.0 | nM | 6.14 | Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant... | 10890169 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10890169 | 10.1016/s0960-894x(00)00245-6 | GABA-A receptor; alpha-1/beta-2/gamma-2 | 1 |
| 10890169 | 10.1016/s0960-894x(00)00245-6 | GABA-A receptor; alpha-2/beta-3/gamma-2 | 1 |
| 10890169 | 10.1016/s0960-894x(00)00245-6 | GABA-A receptor; alpha-3/beta-3/gamma-2 | 1 |
Data from ChEMBL 36 via Core Engine