Compound Detail
CHEMBL299766
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL299766 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PAHRREARFWPKBS-TZMCWYRMSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
355.3
MW (Da)
4.06
ALogP
3
HBA
2
HBD
49.7
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | IC50 | 5.77 | 5.62 | 1700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | IC50 | = | 1700.0 | nM | 5.77 | Antagonistic potency to the human progesterone receptor measured in the T-47D al... | 8627601 |
| Progesterone receptor | IC50 | = | 3400.0 | nM | 5.47 | Concentration required to give half-maximal inhibition against human Progesteron... | 8627601 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8627601 | 10.1021/jm950747d | Progesterone receptor | 6 |
| 8627601 | 10.1021/jm950747d | Glucocorticoid receptor | 1 |
| 8627601 | 10.1021/jm950747d | Androgen receptor | 1 |
| 8627601 | 10.1021/jm950747d | Estrogen receptor | 1 |
Data from ChEMBL 36 via Core Engine