Assay Detail
Functional
CHEMBL642162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic potency to the human progesterone receptor measured in the T-47D alkaline phosphatase assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.54 | 9.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.46 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 8.49 |
| CHEMBL2113712 | — | — | 1 | 7.03 |
| CHEMBL51933 | — | — | 1 | 6.83 |
| CHEMBL48858 | — | — | 1 | 6.79 |
| CHEMBL50023 | — | — | 1 | 6.73 |
| CHEMBL51788 | — | — | 1 | 6.70 |
| CHEMBL50619 | — | — | 1 | 6.68 |
| CHEMBL417729 | — | — | 1 | 6.68 |
| CHEMBL48745 | — | — | 1 | 6.60 |
| CHEMBL48358 | — | — | 1 | 6.55 |
| CHEMBL51669 | — | — | 1 | 6.54 |
| CHEMBL299778 | — | — | 1 | 6.52 |
| CHEMBL50454 | — | — | 1 | 6.46 |
| CHEMBL51093 | — | — | 1 | 6.45 |
| CHEMBL49754 | — | — | 1 | 6.38 |
| CHEMBL50534 | — | — | 1 | 6.37 |
| CHEMBL50849 | — | — | 1 | 6.36 |
| CHEMBL299512 | — | — | 1 | 6.29 |
| CHEMBL54270 | — | — | 1 | 6.11 |
| CHEMBL50786 | — | — | 1 | 6.11 |
| CHEMBL48746 | — | — | 1 | 5.92 |
| CHEMBL299828 | — | — | 1 | 5.89 |
| CHEMBL49978 | — | — | 1 | 5.80 |
| CHEMBL299766 | — | — | 1 | 5.77 |
| CHEMBL296156 | — | — | 1 | 5.70 |
| CHEMBL51639 | — | — | 1 | 5.46 |
| CHEMBL53549 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL2113712 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL51933 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL48858 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL50023 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL51788 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL50619 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL417729 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL48745 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL48358 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL51669 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL299778 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL50454 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL51093 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL49754 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL50534 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL50849 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL299512 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL54270 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL50786 | — | IC50 | = | 775.0 | nM | 6.11 |
| CHEMBL48746 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL299828 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL49978 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL299766 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL296156 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL51639 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL53549 | — | IC50 | > | 10000.0 | nM | - |