Compound Detail
CHEMBL49978
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL49978 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HBEGIVRBESAQLK-VOTSOKGWSA-N |
3
Targets
5
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
377.3
MW (Da)
6.12
ALogP
2
HBA
1
HBD
29.5
PSA (Ų)
0.69
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.08
EC50 1 meas. best 5.48
IC50 1 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | Ki | 7.08 | 7.08 | 84.0 | 1 |
| Progesterone receptor CHEMBL208 | IC50 | 5.8 | 5.8 | 1600.0 | 1 |
| Androgen receptor CHEMBL1871 | Ki | 5.63 | 5.63 | 2318.0 | 1 |
| Progesterone receptor CHEMBL208 | EC50 | 5.48 | 5.48 | 3300.0 | 1 |
| Glucocorticoid receptor CHEMBL2034 | Ki | 5.36 | 5.36 | 4417.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | Ki | = | 84.0 | nM | 7.08 | Binding affinity determined for human Progesterone receptor A isoform | 8627601 |
| Progesterone receptor | IC50 | = | 1600.0 | nM | 5.8 | Antagonistic potency to the human progesterone receptor measured in the T-47D al... | 8627601 |
| Androgen receptor | Ki | = | 2318.0 | nM | 5.63 | Binding affinity determined against human Androgen receptor | 8627601 |
| Progesterone receptor | EC50 | = | 3300.0 | nM | 5.48 | Effective concentration against human Progesterone receptor B isoform expressed ... | 8627601 |
| Glucocorticoid receptor | Ki | = | 4417.0 | nM | 5.36 | Binding affinity was determined for human glucocorticoid receptor(hGR). | 8627601 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8627601 | 10.1021/jm950747d | Progesterone receptor | 6 |
| 8627601 | 10.1021/jm950747d | Glucocorticoid receptor | 1 |
| 8627601 | 10.1021/jm950747d | Androgen receptor | 1 |
| 8627601 | 10.1021/jm950747d | Estrogen receptor | 1 |
Data from ChEMBL 36 via Core Engine