Assay Detail
Binding
CHEMBL766188
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Binding affinity determined for human Progesterone receptor A isoform
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 7.10 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.24 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.46 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 7.75 |
| CHEMBL51933 | — | — | 1 | 7.68 |
| CHEMBL53549 | — | — | 1 | 7.66 |
| CHEMBL299512 | — | — | 1 | 7.54 |
| CHEMBL48746 | — | — | 1 | 7.51 |
| CHEMBL51669 | — | — | 1 | 7.47 |
| CHEMBL50023 | — | — | 1 | 7.27 |
| CHEMBL54270 | — | — | 1 | 7.22 |
| CHEMBL51788 | — | — | 1 | 7.16 |
| CHEMBL299778 | — | — | 1 | 7.15 |
| CHEMBL48858 | — | — | 1 | 7.11 |
| CHEMBL49978 | — | — | 1 | 7.08 |
| CHEMBL50454 | — | — | 1 | 7.08 |
| CHEMBL50786 | — | — | 1 | 7.06 |
| CHEMBL50849 | — | — | 1 | 7.01 |
| CHEMBL299828 | — | — | 1 | 6.96 |
| CHEMBL49754 | — | — | 1 | 6.92 |
| CHEMBL48358 | — | — | 1 | 6.81 |
| CHEMBL417729 | — | — | 1 | 6.66 |
| CHEMBL2113712 | — | — | 1 | 6.61 |
| CHEMBL50534 | — | — | 1 | 6.56 |
| CHEMBL51639 | — | — | 1 | 6.46 |
| CHEMBL48745 | — | — | 1 | 6.36 |
| CHEMBL50619 | — | — | 1 | 6.34 |
| CHEMBL51093 | — | — | 1 | 6.31 |
| CHEMBL296156 | — | — | 1 | 5.49 |
| CHEMBL49966 | — | — | 1 | - |
| CHEMBL299766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL1908373 | ONAPRISTONE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL51933 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL53549 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL299512 | — | Ki | = | 28.8 | nM | 7.54 |
| CHEMBL48746 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL51669 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL50023 | — | Ki | = | 53.5 | nM | 7.27 |
| CHEMBL54270 | — | Ki | = | 59.6 | nM | 7.22 |
| CHEMBL51788 | — | Ki | = | 69.0 | nM | 7.16 |
| CHEMBL299778 | — | Ki | = | 71.0 | nM | 7.15 |
| CHEMBL48858 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL49978 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL50454 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL50786 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL50849 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL299828 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL49754 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL48358 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL417729 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL2113712 | — | Ki | = | 243.0 | nM | 6.61 |
| CHEMBL50534 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL51639 | — | Ki | = | 343.0 | nM | 6.46 |
| CHEMBL48745 | — | Ki | = | 441.0 | nM | 6.36 |
| CHEMBL50619 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL51093 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL296156 | — | Ki | = | 3247.0 | nM | 5.49 |
| CHEMBL49966 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL299766 | — | Ki | 10000.0 | nM | - |