Assay Detail
Binding
CHEMBL681744
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Binding affinity was determined for human glucocorticoid receptor(hGR).
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 5.88 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.17 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 8.26 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.52 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 7.38 |
| CHEMBL53549 | — | — | 1 | 5.99 |
| CHEMBL48746 | — | — | 1 | 5.90 |
| CHEMBL50454 | — | — | 1 | 5.78 |
| CHEMBL51669 | — | — | 1 | 5.75 |
| CHEMBL417729 | — | — | 1 | 5.75 |
| CHEMBL48858 | — | — | 1 | 5.66 |
| CHEMBL54270 | — | — | 1 | 5.66 |
| CHEMBL51788 | — | — | 1 | 5.64 |
| CHEMBL51933 | — | — | 1 | 5.62 |
| CHEMBL51639 | — | — | 1 | 5.61 |
| CHEMBL50849 | — | — | 1 | 5.59 |
| CHEMBL299828 | — | — | 1 | 5.57 |
| CHEMBL48358 | — | — | 1 | 5.56 |
| CHEMBL299778 | — | — | 1 | 5.43 |
| CHEMBL50619 | — | — | 1 | 5.39 |
| CHEMBL49978 | — | — | 1 | 5.36 |
| CHEMBL48745 | — | — | 1 | 5.34 |
| CHEMBL50023 | — | — | 1 | 5.27 |
| CHEMBL296156 | — | — | 1 | 5.20 |
| CHEMBL299512 | — | — | 1 | 5.17 |
| CHEMBL49754 | — | — | 1 | 5.08 |
| CHEMBL50786 | — | — | 1 | 5.08 |
| CHEMBL2113712 | — | — | 1 | 5.07 |
| CHEMBL49966 | — | — | 1 | - |
| CHEMBL50534 | — | — | 1 | - |
| CHEMBL299766 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 0.68 | nM | 9.17 |
| CHEMBL384467 | DEXAMETHASONE | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL103 | PROGESTERONE | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL1908373 | ONAPRISTONE | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL53549 | — | Ki | = | 1036.0 | nM | 5.99 |
| CHEMBL48746 | — | Ki | = | 1261.0 | nM | 5.90 |
| CHEMBL50454 | — | Ki | = | 1657.0 | nM | 5.78 |
| CHEMBL51669 | — | Ki | = | 1777.0 | nM | 5.75 |
| CHEMBL417729 | — | Ki | = | 1766.0 | nM | 5.75 |
| CHEMBL48858 | — | Ki | = | 2206.0 | nM | 5.66 |
| CHEMBL54270 | — | Ki | = | 2199.0 | nM | 5.66 |
| CHEMBL51788 | — | Ki | = | 2286.0 | nM | 5.64 |
| CHEMBL51933 | — | Ki | = | 2379.0 | nM | 5.62 |
| CHEMBL51639 | — | Ki | = | 2465.0 | nM | 5.61 |
| CHEMBL50849 | — | Ki | = | 2570.0 | nM | 5.59 |
| CHEMBL299828 | — | Ki | = | 2670.0 | nM | 5.57 |
| CHEMBL48358 | — | Ki | = | 2781.0 | nM | 5.56 |
| CHEMBL299778 | — | Ki | = | 3697.0 | nM | 5.43 |
| CHEMBL50619 | — | Ki | = | 4109.0 | nM | 5.39 |
| CHEMBL49978 | — | Ki | = | 4417.0 | nM | 5.36 |
| CHEMBL48745 | — | Ki | = | 4532.0 | nM | 5.34 |
| CHEMBL50023 | — | Ki | = | 5424.0 | nM | 5.27 |
| CHEMBL296156 | — | Ki | = | 6386.0 | nM | 5.20 |
| CHEMBL299512 | — | Ki | = | 6812.0 | nM | 5.17 |
| CHEMBL49754 | — | Ki | = | 8215.0 | nM | 5.08 |
| CHEMBL50786 | — | Ki | = | 8356.0 | nM | 5.08 |
| CHEMBL2113712 | — | Ki | = | 8511.0 | nM | 5.07 |
| CHEMBL49966 | — | Ki | 10000.0 | nM | - | |
| CHEMBL50534 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL299766 | — | Ki | > | 10000.0 | nM | - |