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Compound Detail

CHEMBL3039300

UTILIN
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CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@H](c3ccoc3)OC(=O)CC23OC2(C)O[C@]14[C@]1(C)[C@@H](CC(=O)OC)C5(C)CC1(O)[C@](O)(C5OC(=O)C1(C)OC1C)[C@@H](OC(C)=O)[C@]34O2

Basic Information

ChEMBL ID CHEMBL3039300
Name UTILIN
Phase Preclinical
Structure Type MOL
InChI Key HPSILLNWMJOWNM-UJMOMDHXSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

816.9
MW (Da)
2.71
ALogP
17
HBA
2
HBD
225.3
PSA (Ų)
0.21
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C41H52O17
MW 816.85
Aromatic Rings 1
Heavy Atoms 58
NP-Likeness 2.33

Activity Summary

IC50 2 meas. best 6.17
Ki 2 meas. best 6.42

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 6.42 6.42 380.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 6.22 6.22 600.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 6.17 6.17 676.1 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 6.11 6.11 776.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine