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Compound Detail

CHEMBL307961

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COC1=Nc2ccccc2C2=NC(CN3CCN(c4ccccc4)CC3)CN12

Basic Information

ChEMBL ID CHEMBL307961
Phase Preclinical
Structure Type MOL
InChI Key AQFNDEWRDMRIMD-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

375.5
MW (Da)
2.59
ALogP
6
HBA
0
HBD
43.7
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H25N5O
MW 375.48
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.70

Activity Summary

Ki 2 meas. best 8.87

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 8.87 8.87 1.4 1
Adrenergic receptor alpha-2
CHEMBL2093864
Ki 6.02 6.02 952.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8101878 10.1021/jm00067a017 Rattus norvegicus 2
8101878 10.1021/jm00067a017 Adrenergic receptor alpha-1 1
8101878 10.1021/jm00067a017 Adrenergic receptor alpha-2 1
8101878 10.1021/jm00067a017 Adrenergic receptor alpha 1

Data from ChEMBL 36 via Core Engine