Compound Detail
CHEMBL308544
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Basic Information
| ChEMBL ID | CHEMBL308544 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NNXKPIFUBGDIBN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
327.5
MW (Da)
4.48
ALogP
5
HBA
1
HBD
53.9
PSA (Ų)
0.81
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 6.89 | 6.89 | 130.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 130.0 | nM | 6.89 | Inhibition of [125I]CRF binding to human corticotropin releasing factor receptor... | 8893828 |
| Corticotropin-releasing factor receptor 1 | Ki | = | 130.0 | nM | 6.89 | Inhibition of [125I]CRH binding to human Corticotropin releasing factor receptor... | 10395475 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8893828 | 10.1021/jm960148m | Corticotropin-releasing factor receptor 1 | 1 |
| 10395475 | 10.1021/jm9900117 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine