Assay Detail
Binding
CHEMBL663519
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [125I]CRH binding to human Corticotropin releasing factor receptor 1.
19
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pharmacophore development for corticotropin-releasing hormone: new insights into inhibitor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.80 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45281 | — | — | 1 | 8.77 |
| CHEMBL306482 | — | — | 1 | 8.64 |
| CHEMBL75859 | — | — | 1 | 8.60 |
| CHEMBL77716 | — | — | 1 | 8.42 |
| CHEMBL77006 | — | — | 2 | 7.52 |
| CHEMBL306618 | — | — | 1 | 7.24 |
| CHEMBL77391 | — | — | 1 | 6.94 |
| CHEMBL308544 | — | — | 1 | 6.89 |
| CHEMBL307419 | — | — | 1 | 6.31 |
| CHEMBL419636 | — | — | 1 | 6.31 |
| CHEMBL78035 | — | — | 1 | 5.98 |
| CHEMBL305671 | — | — | 1 | 5.98 |
| CHEMBL80806 | — | — | 1 | 5.86 |
| CHEMBL307871 | — | — | 1 | 5.83 |
| CHEMBL78271 | — | — | 1 | 5.77 |
| CHEMBL77527 | — | — | 1 | 5.68 |
| CHEMBL309789 | — | — | 1 | 5.10 |
| CHEMBL78203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45281 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL306482 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL75859 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL77716 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL77006 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL306618 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL77391 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL308544 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL77006 | — | Ki | = | 253.0 | nM | 6.60 |
| CHEMBL419636 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL307419 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL78035 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL305671 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL80806 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL307871 | — | Ki | = | 1470.0 | nM | 5.83 |
| CHEMBL78271 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL77527 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL309789 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL78203 | — | Ki | > | 10000.0 | nM | - |