Compound Detail
CHEMBL77716
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL77716 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZIANMVTWRBZITE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
427.8
MW (Da)
6.68
ALogP
4
HBA
1
HBD
41.0
PSA (Ų)
0.51
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 8.42 | 8.42 | 3.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 3.8 | nM | 8.42 | Inhibition of [125I]CRF binding to human Corticotropin releasing factor receptor... | 8893829 |
| Corticotropin-releasing factor receptor 1 | Ki | = | 3.8 | nM | 8.42 | Inhibition of [125I]CRH binding to human Corticotropin releasing factor receptor... | 10395475 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8893829 | 10.1021/jm960149e | Corticotropin-releasing factor receptor 1 | 1 |
| 10395475 | 10.1021/jm9900117 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine