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Compound Detail

CHEMBL308772

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CCCSc1nsnc1C1=CCCN(C)C1.O=C(O)C(=O)O

Basic Information

ChEMBL ID CHEMBL308772
Phase Preclinical
Structure Type MOL
InChI Key XERBBZHWEILRQK-UHFFFAOYSA-N
Parent Compound CHEMBL1183640
Active Moiety CHEMBL1183640
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

255.4
MW (Da)
2.76
ALogP
5
HBA
0
HBD
29.0
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H19N3O4S2
MW 345.45
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness -0.83

Activity Summary

IC50 3 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 9.05 8.725 0.9 2
Cavia porcellus
CHEMBL369
IC50 7.3 7.3 50.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1613751 10.1021/jm00090a019 Muscarinic acetylcholine receptor M1 2
1613751 10.1021/jm00090a019 Cavia porcellus 2
1613751 10.1021/jm00090a019 Oryctolagus cuniculus 1

Data from ChEMBL 36 via Core Engine