Assay Detail
Functional
CHEMBL692807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of force of contraction in guinea pig atria.
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines .
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 5.92 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74301 | — | — | 1 | 8.00 |
| CHEMBL308772 | — | — | 1 | 7.30 |
| CHEMBL74358 | — | — | 1 | 7.16 |
| CHEMBL308803 | — | — | 1 | 7.05 |
| CHEMBL306941 | — | — | 1 | 7.00 |
| CHEMBL420007 | — | — | 1 | 6.70 |
| CHEMBL308608 | — | — | 1 | 6.52 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 6.30 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 6.22 |
| CHEMBL72908 | — | — | 1 | 5.96 |
| CHEMBL75552 | — | — | 1 | 5.55 |
| CHEMBL76161 | — | — | 1 | 5.41 |
| CHEMBL307837 | — | — | 1 | 5.27 |
| CHEMBL308381 | — | — | 1 | 5.27 |
| CHEMBL75704 | — | — | 1 | 5.26 |
| CHEMBL76107 | — | — | 1 | 5.14 |
| CHEMBL73338 | — | — | 1 | 5.12 |
| CHEMBL309093 | — | — | 1 | 5.01 |
| CHEMBL308168 | — | — | 1 | 4.89 |
| CHEMBL76296 | — | — | 1 | 4.60 |
| CHEMBL307645 | — | — | 1 | 4.53 |
| CHEMBL75907 | — | — | 1 | - |
| CHEMBL442369 | — | — | 1 | - |
| CHEMBL74300 | — | — | 1 | - |
| CHEMBL73709 | — | — | 1 | - |
| CHEMBL73431 | — | — | 1 | - |
| CHEMBL72384 | — | — | 1 | - |
| CHEMBL306395 | — | — | 1 | - |
| CHEMBL74786 | — | — | 1 | - |
| CHEMBL73408 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74301 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL308772 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL74358 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL308803 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL306941 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL420007 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL308608 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL14 | CARBACHOL | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL72908 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL75552 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL76161 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL307837 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL308381 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL75704 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL76107 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL73338 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL309093 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL308168 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL76296 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL307645 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL75907 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL442369 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL74300 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL73709 | — | IC50 | > | 72000.0 | nM | - |
| CHEMBL73431 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL72384 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL306395 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL74786 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL73408 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL308744 | — | IC50 | > | 75000.0 | nM | - |
| CHEMBL73149 | — | IC50 | > | 27000.0 | nM | - |
| CHEMBL73741 | — | IC50 | > | 7500.0 | nM | - |
| CHEMBL72430 | — | IC50 | > | 75000.0 | nM | - |