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Compound Detail

CHEMBL308803

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CCCOc1nsnc1C1=CCCN(C)C1.O=C(O)C(=O)O

Basic Information

ChEMBL ID CHEMBL308803
Phase Preclinical
Structure Type MOL
InChI Key ABAUZZHICDLXNZ-UHFFFAOYSA-N
Parent Compound CHEMBL303922
Active Moiety CHEMBL303922
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

239.3
MW (Da)
2.05
ALogP
5
HBA
0
HBD
38.2
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H19N3O5S
MW 329.38
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness -0.82

Activity Summary

IC50 3 meas. best 8.8

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL276
IC50 8.8 8.275 1.6 2
Cavia porcellus
CHEMBL369
IC50 7.05 7.05 90.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1613751 10.1021/jm00090a019 Muscarinic acetylcholine receptor M1 2
1613751 10.1021/jm00090a019 Cavia porcellus 2
1613751 10.1021/jm00090a019 Oryctolagus cuniculus 1

Data from ChEMBL 36 via Core Engine