Compound Detail
CHEMBL3092828
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Basic Information
| ChEMBL ID | CHEMBL3092828 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WHVIDDBOZMFAKP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
336.4
MW (Da)
4.03
ALogP
4
HBA
0
HBD
42.4
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Ki | 10.0 | 10.0 | 0.1 | 1 |
| Histamine H3 receptor CHEMBL4124 | Ki | 9.2 | 9.2 | 0.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 0.1 | nM | 10.0 | Antagonist activity at human histamine H3 receptor expressed in CHOK1 cells asse... | 24269482 |
| Histamine H3 receptor | Ki | = | 0.631 | nM | 9.2 | Displacement of [3H]-R-alpha-ethylhistamine from histamine H3 receptor in rat ce... | 24269482 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24269482 | 10.1016/j.bmcl.2013.09.090 | Histamine H3 receptor | 2 |
| 24269482 | 10.1016/j.bmcl.2013.09.090 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine