Compound Detail
CHEMBL309307
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Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1CNC(=O)c1ccccc1
Basic Information
| ChEMBL ID | CHEMBL309307 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMTCEUXGAGRBNX-OZXSUGGESA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
457.6
MW (Da)
3.26
ALogP
4
HBA
3
HBD
95.7
PSA (Ų)
0.53
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.62
EC50 1 meas. best 6.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Delta-type opioid receptor CHEMBL236 | IC50 | 9.62 | 9.62 | 0.2 | 1 |
| Mu-type opioid receptor CHEMBL233 | IC50 | 9.01 | 9.01 | 1.0 | 1 |
| Mu-type opioid receptor CHEMBL233 | EC50 | 6.96 | 6.96 | 109.0 | 1 |
| Kappa-type opioid receptor CHEMBL237 | IC50 | 6.51 | 6.51 | 307.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Delta-type opioid receptor | IC50 | = | 0.24 | nM | 9.62 | Binding affinity at cloned human delta-opioid receptor | 11448220 |
| Mu-type opioid receptor | IC50 | = | 0.98 | nM | 9.01 | Binding affinity at cloned human mu-opioid receptor | 11448220 |
| Mu-type opioid receptor | EC50 | = | 109.0 | nM | 6.96 | Agonist potency using GTP-gamma [35S]- binding assay for mu-opioid receptor | 11448220 |
| Kappa-type opioid receptor | IC50 | = | 307.0 | nM | 6.51 | Binding affinity at cloned human opioid receptor kappa 1 | 11448220 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11448220 | 10.1021/jm015532k | Mu-type opioid receptor | 3 |
| 11448220 | 10.1021/jm015532k | Delta-type opioid receptor | 2 |
| 11448220 | 10.1021/jm015532k | Kappa-type opioid receptor | 1 |
| 11448220 | 10.1021/jm015532k | Opioid receptors; mu & delta | 1 |
| 11448220 | 10.1021/jm015532k | Opioid receptors; delta & kappa | 1 |
Data from ChEMBL 36 via Core Engine