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Compound Detail

CHEMBL3099658

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COc1ccc(CCNC[C@@H](O)c2cc(O)cc(O)c2)cc1

Basic Information

ChEMBL ID CHEMBL3099658
Phase Preclinical
Structure Type MOL
InChI Key CCADMOBPNSAPBP-QGZVFWFLSA-N
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

303.4
MW (Da)
1.97
ALogP
5
HBA
4
HBD
82.0
PSA (Ų)
0.59
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H21NO4
MW 303.36
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.19

Activity Summary

Ki 2 meas. best 5.94
EC50 1 meas. best 6.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 6.68 6.68 210.0 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 5.94 5.94 1150.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24326276 10.1016/j.bmc.2013.11.030 Beta-2 adrenergic receptor 5

Data from ChEMBL 36 via Core Engine