Assay Detail
Functional
CHEMBL3100636
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Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 7.26 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 9.70 |
| CHEMBL228992 | — | — | 1 | 9.52 |
| CHEMBL3099659 | — | — | 1 | 8.79 |
| CHEMBL228996 | — | — | 1 | 8.70 |
| CHEMBL228998 | — | — | 1 | 8.14 |
| CHEMBL3099657 | — | — | 1 | 7.99 |
| CHEMBL228417 | — | — | 1 | 7.48 |
| CHEMBL3099658 | — | — | 1 | 6.68 |
| CHEMBL3099663 | — | — | 1 | 6.33 |
| CHEMBL3099660 | — | — | 1 | 6.00 |
| CHEMBL3099664 | — | — | 1 | 5.21 |
| CHEMBL3099662 | — | — | 1 | 5.21 |
| CHEMBL3099661 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL228992 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3099659 | — | EC50 | = | 1.63 | nM | 8.79 |
| CHEMBL228996 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL228998 | — | EC50 | = | 7.2 | nM | 8.14 |
| CHEMBL3099657 | — | EC50 | = | 10.19 | nM | 7.99 |
| CHEMBL228417 | — | EC50 | = | 33.2 | nM | 7.48 |
| CHEMBL3099658 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3099663 | — | EC50 | = | 462.0 | nM | 6.33 |
| CHEMBL3099660 | — | EC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3099664 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3099662 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL3099661 | — | EC50 | = | 26200.0 | nM | 4.58 |