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Compound Detail

CHEMBL3099663

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CCC[C@H](Cc1ccc(OC)cc1)NC[C@H](O)c1cc(O)cc(O)c1

Basic Information

ChEMBL ID CHEMBL3099663
Phase Preclinical
Structure Type MOL
InChI Key HOCMNYATHYZPNH-UZLBHIALSA-N
1
Targets
4
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

345.4
MW (Da)
3.14
ALogP
5
HBA
4
HBD
82.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H27NO4
MW 345.44
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness 0.37

Activity Summary

Ki 3 meas. best 6.6
EC50 1 meas. best 6.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 6.6 6.1067 250.0 3
Beta-2 adrenergic receptor
CHEMBL210
EC50 6.33 6.33 462.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24326276 10.1016/j.bmc.2013.11.030 Beta-2 adrenergic receptor 5

Data from ChEMBL 36 via Core Engine