Assay Detail
Binding
CHEMBL3100638
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.31 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 9.34 |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 6.72 |
| CHEMBL3099659 | — | — | 1 | 6.38 |
| CHEMBL3099657 | — | — | 1 | 5.57 |
| CHEMBL3099663 | — | — | 1 | 5.12 |
| CHEMBL3099660 | — | — | 1 | 4.70 |
| CHEMBL3099658 | — | — | 1 | - |
| CHEMBL3099664 | — | — | 1 | - |
| CHEMBL3099662 | — | — | 1 | - |
| CHEMBL3099661 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27 | PROPRANOLOL | Ki | = | 0.46 | nM | 9.34 |
| CHEMBL434 | ISOPROTERENOL | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL3099659 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL3099657 | — | Ki | = | 2670.0 | nM | 5.57 |
| CHEMBL3099663 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL3099660 | — | Ki | = | 20100.0 | nM | 4.70 |
| CHEMBL3099658 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3099664 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3099662 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL3099661 | — | Ki | > | 100000.0 | nM | - |