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Compound Detail

CHEMBL310912

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COc1ccc(S(=O)(=O)c2ccc(C(C)N3CCN(C4CCCCC4)CC3)cc2)cc1

Basic Information

ChEMBL ID CHEMBL310912
Phase Preclinical
Structure Type MOL
InChI Key AWMYFVQONDTWPK-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

442.6
MW (Da)
4.54
ALogP
5
HBA
0
HBD
49.9
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H34N2O3S
MW 442.63
Aromatic Rings 2
Heavy Atoms 31
NP-Likeness -1.01

Activity Summary

Ki 3 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 9.22 9.22 0.6 2
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 8.22 8.22 6.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11859004 10.1016/s0960-894x(02)00023-9 Muscarinic acetylcholine receptor M2 1
11859004 10.1016/s0960-894x(02)00023-9 Muscarinic acetylcholine receptor M1 1
11055332 10.1016/s0960-894x(00)00438-8 Muscarinic acetylcholine receptor M1 1
11055332 10.1016/s0960-894x(00)00438-8 Muscarinic acetylcholine receptor M2 1
11055332 10.1016/s0960-894x(00)00438-8 Muscarinic acetylcholine receptors; M1 & M2 1

Data from ChEMBL 36 via Core Engine