Assay Detail
Binding
CHEMBL748899
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Binding affinity towards the cloned human Muscarinic acetylcholine receptor M2
21
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 8.00 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312085 | — | — | 1 | 9.70 |
| CHEMBL75448 | — | — | 1 | 9.22 |
| CHEMBL310912 | — | — | 1 | 9.22 |
| CHEMBL72455 | — | — | 1 | 9.10 |
| CHEMBL307810 | — | — | 1 | 9.00 |
| CHEMBL2111540 | — | — | 5 | 8.57 |
| CHEMBL70464 | — | — | 1 | 8.30 |
| CHEMBL73341 | — | — | 1 | 8.10 |
| CHEMBL421304 | — | — | 1 | 7.77 |
| CHEMBL70531 | — | — | 1 | 7.58 |
| CHEMBL73661 | — | — | 1 | 7.48 |
| CHEMBL73410 | — | — | 1 | 7.47 |
| CHEMBL72956 | — | — | 1 | 7.44 |
| CHEMBL71088 | — | — | 1 | 7.43 |
| CHEMBL431787 | — | — | 1 | 7.40 |
| CHEMBL73145 | — | — | 1 | 6.87 |
| CHEMBL303443 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312085 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL75448 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL310912 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL72455 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL307810 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL2111540 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL2111540 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL70464 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL73341 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2111540 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL421304 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2111540 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL2111540 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL70531 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL73661 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL73410 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL72956 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL71088 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL431787 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL73145 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL303443 | — | Ki | = | 4600.0 | nM | 5.34 |