Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL75448

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(c1ccc(S(=O)(=O)c2ccc(Cl)cc2)cc1)N1CCN(C2CCCCC2)CC1

Basic Information

ChEMBL ID CHEMBL75448
Phase Preclinical
Structure Type MOL
InChI Key CZMLHCKAVIBNFO-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

447.0
MW (Da)
5.18
ALogP
4
HBA
0
HBD
40.6
PSA (Ų)
0.63
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H31ClN2O2S
MW 447.04
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness -1.22

Activity Summary

Ki 2 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 9.22 9.22 0.6 1
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 8.1 8.1 8.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11055332 10.1016/s0960-894x(00)00438-8 Muscarinic acetylcholine receptor M1 1
11055332 10.1016/s0960-894x(00)00438-8 Muscarinic acetylcholine receptor M2 1
11055332 10.1016/s0960-894x(00)00438-8 Muscarinic acetylcholine receptors; M1 & M2 1

Data from ChEMBL 36 via Core Engine