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Compound Detail

CHEMBL3114392

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O=C(Nc1ncc([N+](=O)[O-])s1)NC1CCCCC1

Basic Information

ChEMBL ID CHEMBL3114392
Phase Preclinical
Structure Type MOL
InChI Key NUXSOIASURUVAU-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

270.3
MW (Da)
2.51
ALogP
5
HBA
2
HBD
97.2
PSA (Ų)
0.65
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H14N4O3S
MW 270.31
Aromatic Rings 1
Heavy Atoms 18
NP-Likeness -2.26

Activity Summary

IC50 4 meas. best 6.45

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Giardia intestinalis
CHEMBL612652
IC50 6.45 6.445 359.0 2
Trichomonas vaginalis
CHEMBL612884
IC50 5.78 5.74 1650.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
24529307 10.1016/j.bmc.2014.01.029 Giardia intestinalis 3
24529307 10.1016/j.bmc.2014.01.029 Trichomonas vaginalis 2
24529307 10.1016/j.bmc.2014.01.029 Vero 1
24529307 10.1016/j.bmc.2014.01.029 Trypanosoma cruzi 1
24529307 10.1016/j.bmc.2014.01.029 Leishmania amazonensis 1

Data from ChEMBL 36 via Core Engine