Compound Detail
CHEMBL311860
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Basic Information
| ChEMBL ID | CHEMBL311860 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QAZCHQANHOZOBJ-UHFFFAOYSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
275.2
MW (Da)
0.59
ALogP
8
HBA
2
HBD
143.8
PSA (Ų)
0.51
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 4.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | Ki | 4.97 | 4.97 | 10700.0 | 3 |
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 4.1 | 4.1 | 79400.0 | 1 |
| Glutamate receptor ionotropic, NMDA 1 CHEMBL330 | Ki | 4.1 | 4.1 | 79400.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | Ki | = | 10700.0 | nM | 4.97 | Binding selectivity towards Ionotropic glutamate receptor AMPA was determined by... | 12954059 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 10700.0 | nM | 4.97 | Binding affinity towards ionotropic glutamate receptor AMPA in rat cortical memb... | 10395489 |
| Glutamate receptor ionotropic, AMPA | Ki | = | 10700.0 | nM | 4.97 | Binding affinity at ionotropic glutamate receptor AMPA in rat cortical membranes... | 11543685 |
| Glutamate receptor ionotropic, NMDA 1 | Ki | = | 79400.0 | nM | 4.1 | Binding selectivity towards N-methyl-D-aspartate glutamate receptor 1 was determ... | 12954059 |
| Glutamate receptor ionotropic, NMDA 1 | Ki | = | 79400.0 | nM | 4.1 | Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 in rat cortic... | 10395489 |
| Glutamate NMDA receptor | Ki | = | 79400.0 | nM | 4.1 | Ability to displace [3H]glycine from NMDA receptor in rat corticaln membranes | 11543685 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10395489 | 10.1021/jm981102r | Glutamate receptor ionotropic, NMDA 1 | 2 |
| 12954059 | 10.1021/jm030833a | Glutamate receptor ionotropic, AMPA | 1 |
| 12954059 | 10.1021/jm030833a | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 10395489 | 10.1021/jm981102r | Glutamate receptor ionotropic, AMPA | 1 |
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, AMPA | 1 |
| 11543685 | 10.1021/jm010862q | Glutamate NMDA receptor | 1 |
| 11543685 | 10.1021/jm010862q | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine