Compound Detail
CHEMBL3134130
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Basic Information
| ChEMBL ID | CHEMBL3134130 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AGBQCCLLKQVTAO-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
362.0
MW (Da)
4.04
ALogP
3
HBA
0
HBD
9.7
PSA (Ų)
0.78
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 CHEMBL1287623 | IC50 | 7.43 | 7.43 | 37.0 | 1 |
| Lethal(3)malignant brain tumor-like protein 1 CHEMBL1287622 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
| TP53-binding protein 1 CHEMBL2424509 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Lethal(3)malignant brain tumor-like protein 3 | IC50 | = | 37.0 | nM | 7.43 | Inhibition of His-tagged L3MBTL3 (unknown origin) using H4K20Me2 as substrate in... | 24466405 |
| TP53-binding protein 1 | IC50 | = | 21000.0 | nM | 4.68 | Inhibition of 53BP1 (1485 to 1611) (unknown origin) expressed in Escherichia col... | 24466405 |
| Lethal(3)malignant brain tumor-like protein 1 | IC50 | = | 21000.0 | nM | 4.68 | Inhibition of His-tagged L3MBTL1 (unknown origin) using H4K20Me1 as substrate in... | 24466405 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24466405 | 10.1039/c3md00197k | PHD finger protein 23 | 1 |
| 24466405 | 10.1039/c3md00197k | Lysine-specific demethylase 5A | 1 |
| 24466405 | 10.1039/c3md00197k | E3 ubiquitin-protein ligase UHRF1 | 1 |
| 24466405 | 10.1039/c3md00197k | Chromobox protein homolog 7 | 1 |
| 24466405 | 10.1039/c3md00197k | TP53-binding protein 1 | 1 |
| 24466405 | 10.1039/c3md00197k | MBT domain-containing protein 1 | 1 |
| 24466405 | 10.1039/c3md00197k | Lethal(3)malignant brain tumor-like protein 1 | 1 |
| 24466405 | 10.1039/c3md00197k | Lethal(3)malignant brain tumor-like protein 3 | 1 |
Data from ChEMBL 36 via Core Engine