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Compound Detail

CHEMBL3137741

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CC(C)=CCC[C@]1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)O[C@]12C(C[C@@H]4C[C@H]1C(C)(C)O[C@@]2(C/C=C(/C)C(=O)O)C4O)C3=O

Basic Information

ChEMBL ID CHEMBL3137741
Phase Preclinical
Structure Type MOL
InChI Key CXFIQFGADOTDPF-CMLKYFHXSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

632.8
MW (Da)
7.11
ALogP
7
HBA
3
HBD
122.5
PSA (Ų)
0.20
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C38H48O8
MW 632.79
Aromatic Rings 1
Heavy Atoms 46
NP-Likeness 3.09

Activity Summary

IC50 2 meas. best 5.7
Ki 2 meas. best 5.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 5.96 5.96 1100.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.7 5.7 1995.3 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.67 5.67 2160.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.55 5.55 2818.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine