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Compound Detail

CHEMBL3138652

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CC1(C)[C@@H](O)C=C[C@]2(C)[C@H]3CC[C@@]4(C)[C@H](c5ccoc5)OC(=O)[C@H]5O[C@]54[C@]3(C)C(=O)C[C@@H]12

Basic Information

ChEMBL ID CHEMBL3138652
Phase Preclinical
Structure Type MOL
InChI Key APNJDIVXMGGHDX-PESSHVGISA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

440.5
MW (Da)
3.99
ALogP
6
HBA
1
HBD
89.3
PSA (Ų)
0.40
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H32O6
MW 440.54
Aromatic Rings 1
Heavy Atoms 32
NP-Likeness 3.12

Activity Summary

IC50 2 meas. best 5.62
Ki 2 meas. best 5.88

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 5.88 5.88 1330.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.62 5.62 2398.8 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.42 5.42 3810.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.3 5.3 5011.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine