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Compound Detail

CHEMBL3138664

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CC1(C)C(=O)CC[C@]2(C)[C@@H]1C[C@@H](O)[C@]1(C)C3=CC(=O)O[C@H](c4ccoc4)[C@@]3(C)CC[C@@H]21

Basic Information

ChEMBL ID CHEMBL3138664
Phase Preclinical
Structure Type MOL
InChI Key BQDRKSSNLHIYIM-FGYUCKKHSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

426.6
MW (Da)
5.00
ALogP
5
HBA
1
HBD
76.7
PSA (Ų)
0.64
QED
1
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C26H34O5
MW 426.55
Aromatic Rings 1
Heavy Atoms 31
NP-Likeness 3.39

Activity Summary

IC50 2 meas. best 5.48
Ki 2 meas. best 5.59

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.59 5.59 2550.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.48 5.48 3311.3 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 5.46 5.46 3440.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.2 5.2 6309.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine