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Compound Detail

CHEMBL3138678

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CC(=O)O[C@H]1C[C@@H](OC(C)=O)C(C)(C)[C@@H]2C[C@@H](OC(C)=O)[C@]3(C)[C@H]([C@H](OC(C)=O)C[C@@]4(C)[C@H](c5ccoc5)OC(=O)[C@H]5O[C@@]534)[C@@]12C

Basic Information

ChEMBL ID CHEMBL3138678
Phase Preclinical
Structure Type MOL
InChI Key RPPVTVIFAKGTDU-SZEXXHSXSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

644.7
MW (Da)
4.23
ALogP
12
HBA
0
HBD
157.2
PSA (Ų)
0.26
QED
2
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C34H44O12
MW 644.71
Aromatic Rings 1
Heavy Atoms 46
NP-Likeness 2.62

Activity Summary

IC50 2 meas. best 6.06
Ki 2 meas. best 6.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 6.32 6.32 480.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 6.06 6.06 871.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.52 5.52 3050.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.4 5.4 3981.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine