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Compound Detail

CHEMBL3138701

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CC(=O)O[C@@H]1C[C@@H]2C(C)(C)[C@H](O)C=C[C@@]2(C)[C@@H]2CC[C@@]3(C)C(=CC(=O)O[C@@H]3c3ccoc3)[C@@]12C

Basic Information

ChEMBL ID CHEMBL3138701
Phase Preclinical
Structure Type MOL
InChI Key YIEIZLQDUWWSED-CRHINSDJSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

468.6
MW (Da)
5.14
ALogP
6
HBA
1
HBD
86.0
PSA (Ų)
0.48
QED
1
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C28H36O6
MW 468.59
Aromatic Rings 1
Heavy Atoms 34
NP-Likeness 3.28

Activity Summary

IC50 2 meas. best 5.66
Ki 2 meas. best 5.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 5.92 5.92 1210.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.66 5.66 2187.8 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.54 5.54 2890.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.43 5.43 3715.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine