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Compound Detail

CHEMBL3138712

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CC(=O)O[C@H]1C[C@@H](OC(C)=O)C(C)(C)[C@@H]2C[C@@H](O)[C@@]3(C)[C@H](CC[C@]4(C)[C@@H](c5ccoc5)OC(=O)[C@H]5O[C@@]534)[C@@]12C

Basic Information

ChEMBL ID CHEMBL3138712
Phase Preclinical
Structure Type MOL
InChI Key MRMHZWKIOFZZID-VRULEFBYSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

544.6
MW (Da)
4.12
ALogP
9
HBA
1
HBD
124.8
PSA (Ų)
0.34
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C30H40O9
MW 544.64
Aromatic Rings 1
Heavy Atoms 39
NP-Likeness 3.05

Activity Summary

IC50 2 meas. best 6.01
Ki 2 meas. best 6.27

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 6.27 6.27 540.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 6.01 6.01 977.2 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.64 5.64 2270.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.53 5.53 2951.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine