Compound Detail
CHEMBL320656
DEXCLAMOL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL320656 |
| Name | DEXCLAMOL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UPMOVJBGNREKJV-CQOQZXRMSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
1
Known Names
Molecular Properties
347.5
MW (Da)
4.45
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.82
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
IC50 1 meas. best 6.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | IC50 | 6.05 | 6.05 | 900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | IC50 | = | 900.0 | nM | 6.05 | Binding affinity against Dopamine receptor D2 using [3H]spiroperidol | 2892932 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31480 | 10.1021/jm00210a011 | Rattus norvegicus | 5 |
| 2892932 | 10.1021/jm00397a006 | Rattus norvegicus | 2 |
| 2892932 | 10.1021/jm00397a006 | D(2) dopamine receptor | 1 |
Data from ChEMBL 36 via Core Engine