Assay Detail
Binding
CHEMBL672659
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Binding affinity against Dopamine receptor D2 using [3H]spiroperidol
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Conformational analysis and structural comparisons of (1R,3S)-(+)- and (1S,3R)-(-)-tefludazine, (S)-(+)- and (R)-(-)-octoclothepin, and (+)-dexclamol in relation to dopamine receptor antagonism and amine-uptake inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.06 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303313 | — | — | 1 | 8.35 |
| CHEMBL104911 | — | — | 1 | 8.22 |
| CHEMBL1255588 | — | — | 1 | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | 2.0 | 1 | 7.85 |
| CHEMBL64875 | — | — | 1 | 7.40 |
| CHEMBL105013 | — | — | 1 | 6.23 |
| CHEMBL320656 | DEXCLAMOL | 2.0 | 1 | 6.05 |
| CHEMBL6066837 | (-)-BUTACLAMOL | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303313 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL104911 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1255588 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL95636 | TEFLUDAZINE | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL64875 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL105013 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL320656 | DEXCLAMOL | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL6066837 | (-)-BUTACLAMOL | IC50 | = | 34000.0 | nM | 4.47 |