Compound Detail
CHEMBL323331
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CCC(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)[C@@H](C)CC)[C@@H](C)CC)C(c1ccccc1)c1ccccc1
Basic Information
| ChEMBL ID | CHEMBL323331 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ASPXCZHJJMKYNZ-LCHPGPOGSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
938.1
MW (Da)
4.56
ALogP
8
HBA
9
HBD
265.0
PSA (Ų)
0.04
QED
2
Ro5 Violations
26
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Endothelin receptor type B CHEMBL4631 | IC50 | 6.66 | 6.62 | 220.0 | 2 |
| Endothelin-1 receptor CHEMBL252 | IC50 | 6.64 | 6.32 | 230.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Endothelin receptor type B | IC50 | = | 220.0 | nM | 6.66 | Inhibition of ET-1 stimulated arachidonic acid release in CHO cells expressing r... | 7636842 |
| Endothelin-1 receptor | IC50 | = | 230.0 | nM | 6.64 | Inhibition of ET-1 stimulated arachidonic acid release in rabbit renal vascular ... | 7636842 |
| Endothelin receptor type B | IC50 | = | 260.0 | nM | 6.58 | Binding affinity against endothelin B receptor rat cerebellar membranes. | 7636842 |
| Endothelin-1 receptor | IC50 | = | 1000.0 | nM | 6.0 | Binding affinity against endothelin A receptor from rabbit renal vascular smooth... | 7636842 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7636842 | 10.1021/jm00015a003 | Endothelin-1 receptor | 2 |
| 7636842 | 10.1021/jm00015a003 | Endothelin receptor type B | 2 |
| 7636842 | 10.1021/jm00015a003 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine