Compound Detail
CHEMBL324057
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Basic Information
| ChEMBL ID | CHEMBL324057 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJHCSFKCWMDCCD-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
356.5
MW (Da)
2.96
ALogP
5
HBA
1
HBD
59.3
PSA (Ų)
0.90
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL4317 | EC50 | 7.39 | 7.39 | 40.3 | 1 |
| 5-hydroxytryptamine receptor 4 CHEMBL2183 | EC50 | 7.14 | 7.14 | 72.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | EC50 | = | 40.3 | nM | 7.39 | Efficient 5-hydroxytryptamine 4 agonist in the rat tunica muscularis mucosae | 12540230 |
| 5-hydroxytryptamine receptor 4 | EC50 | = | 72.0 | nM | 7.14 | Tested for ability to stimulate production of cAMP mediated by 5-hydroxytryptami... | 12540230 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12540230 | 10.1021/jm020099f | 5-hydroxytryptamine receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine